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Simvastatin inhibits activation of nadph oxidase/p38 mapk pathway and enhances expression of antioxidant protein in parkinson disease models

This indicates that antioxidant property of Sp encompasses replenishment of intracellular glutathione, probably through inhibition of its breakdown

Glutathione is a critical component of the liver's natural "cleansing" process

Nrf2-mediated response to xenobiotic and oxidative stress Nrf2 controls the expression of key components of the glutathione (GSH) and thioredoxin (TXN) antioxidant system, as well as enzymes involved in NADPH regeneration, ROS and xenobiotic detoxification, heme metabolism, thus playing a fundamental role in maintaining the redox homeostasis of the cell (Fig

In GSTFs, aromatic residues identified by mutagenesis studies have been clearly demonstrated as participating in the affinity toward electrophilic substrates ( FIGURE 2 The structures of GSTs include other important regions that are associated with non-catalytic functions