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Copper is an important fungicide in organic viticulture and also an important catalyst in the wine-making process ( DLAT , GLS , and CDKN2A are closely associated with ALD ( GLS and CDKN2A exhibit a correlation with the p53 pathway, which can increase cellular sensitivity to cuproptosis through multiple pathways, such as inhibiting glycolysis, enhancing mitochondrial function and Fe-S cluster biogenesis, and inhibiting the SLC7A11-glutathione peroxidase 4 (GPX4)-GSH pathway to reduce GSH levels (9395)

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