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CVD is characterized by inflammation induced atherosclerotic complications, resulting from an increase of lipid particles to the endothelial cells causing foam cell and the resultant plaque formation ( Other comorbidities associated with T2D are hypertension, dyslipidemia, and renal insufficiency ( As T2D progresses, hyperinsulinemia, hyperglycemia, and oxidized LDL culminates in endothelial cell dysfunction and apoptosis ( Complicating CVD in T2D patients is the common association of combined hyperlipidemia, a pro-atherogenic lipid disorder, characterized by high levels of LDL, triglycerides (TGs), and decreased levels of HDL ( Current pharmacological therapies for T2D, when in conjunction with CVD, attempt to reduce associated risks through tight glycemic control, dietary changes, and statin drugs

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Using the prize-collecting Steiner tree algorithm, it searches the PPMI interactome to find an optimum subnetwork that connects the input metabolite peaks via their putative identities and other metabolites and proteins that were not detected in the experiments

They might recommend focusing on dietary changes to boost natural L-Carnitine intake or suggest adding supplements as part of a broader PCOS management plan
(Berl.) 2003;81:435442

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