glutathione recycling and autophagy depletion induces ferroptosis, autophagy, premature cell senescence in retinal pigment epithelial cells The interplay of autophagy and

It causes activation of the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system

Approximately, half of the pelleted cells were stored at 80 C until DNA extraction

Ferroptosis is an iron-dependent regulated necrosis that is considered a byproduct of cellular metabolism because of its close association with oxygen, iron, and lipid metabolism (116), it is dependent on the metabolites reactive oxygen species (ROS), phospholipids containing polyunsaturated fatty acid chains (PUFA-PL), and the transition metal iron, and exhibits biochemical features of iron accumulation and unrestricted lipid peroxidation, as well as morphologic alterations such as loss of plasma membrane integrity, mitochondrial abnormalities, cytoplasmic swelling, and moderate chromatin condensation (117, 118)

The discovery and development of lg and GLP1

10.1016/j.ejphar.2013.11.007 37 ChenY.HuangJ

The experiment was carried out between 11.00 and 12.00 h at light-saturating intensity, 2 cm 2 of leaf area, block temperature (25 C), CO 2 flow controller (300 mol s 1 ) and PAR (1600 mol photons m 2 s 1 )