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This section summarizes current research progress on mitochondrial biogenesis, mitophagy, and mitochondrial dynamics in common neurodegenerative diseases (AD, PD, HD, and ALS) (Figure 5)

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These events impair axonal transport, damage the blood-nerve barrier, and inhibit myelin regeneration, ultimately leading to progressive demyelination and axonal degeneration (Wang et al., 2020a

However, type I interferon pathway was strongly activated in B16-F10 when we used specific agonists to TLR3 (Poly I:C) or cGAS-STING (dsDNA90) ( Figures 2G, H )

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