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Passenger mutations confound phenotypes of SARM1-deficient mice

Approach Phase 2b trial arm Duration 24 weeks Review Point Week 12 and 24 Notes METAOD006 (OPTIONS) used 24 weeks at oral doses 0.25, 0.5, or 1 mg/day in 502 obese adults

Nevertheless, they may eventually experience disease progression, indicating development of resistance to anti-CD38 antibody therapy

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