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Targeting DC antigen presentation or their interaction with CD8 + T cells could therefore disrupt a key step in the autoimmune cascade

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Pharmacological regulation of eIF2B depends on the latch-helix While NSs and AcP10 access the eIF2-P binding pocket to regulate eIF2B, ISRIB functions as an ISR inhibitor by binding a distinct pocket formed by the twofold symmetry interface between the - and -subunits in eIF2B, ~50 from the binding sites of these viral effectors 4,5,65,66

Other amino acids, including L-alanine, L-leucine, L-glutamine, L-arginine and L-methionine are not transported in significant amounts