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Collectively, these HIV-related mechanisms link Ca 2+ signals (for activation via CaSR and Ca 2+ mobilization) with K + efflux (as the proximal activation signal), integrating ion fluxes with microglial sensing and inflammasome priming/activation

The foundational studies by Monnier, Schoenenberger, and colleagues who first isolated DSIP from rabbit brain venous blood during electrically-induced sleep demonstrated that intravenous or intraventricular administration of DSIP to rabbits and rats could induce behavioral and EEG changes consistent with sleep, particularly increases in slow-wave sleep

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Statistical Analysis SPSS software (v24.0) was used for statistical analysis of the data

others enforce a once-per-year limit

For example, hepatocyte growth factor (HGF) produced by tumor-associated fibroblasts (CAFs) and macrophages (TAMs) activates survival pathways, reinforcing temporary drug-tolerance (Heynen et al., 2014