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Hyperhomocysteinemia is implicated in the pathogenesis of vascular dementia, AD, PD, and other neurodegenerative disorders

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Mechano Growth Factor (MGF) is produced by skeletal muscle in response to mechanical loading, eccentric exercise, or injury through alternative splicing at exon 5 of the IGF-1 gene, generating a C-terminal extension peptide (the Ec peptide) that is unique to MGF and absent from systemic IGF-1
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The n's in all figures reflect separate experiments not separate plates of cells

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