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G6PD deficiency is widespread in malaria-endemic areas, consequent on malaria having been the selective agent for this polymorphism

Your child will be given glasses to wear during treatment to make sure the light does not bother their eyes

10.1007/s00417-024-06388-y 33

Mitochondrial ROS (OH) also activate the NLRP3 inflammasome, promoting Caspase-1-mediated cleavage of GSDMD to form plasma membrane pores and release IL-1, thereby linking pyroptosis and inflammation [199]

Figure 1 illustrates the principal findings related to SCOPA