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The rationale behind this exception is these drugs do not have a diuretic effect when topically applied

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For others, especially if their levels have been low for a while, it can take a few weeks and more than one injection to feel the full benefit
10.1186/s40035-024-00430-z Transl Neurodegener

Beneficial genera, including Alitipes , Bifidobacterium , Lactobacillus , and Olsenella , were depleted in the PL group