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456 However, a Phase II clinical study involving 12 patients with recurrent and/or refractory germ cell tumors failed to achieve its primary endpoint

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Oxidative GPX4 inactivation is obviously a crucial step in sperm maturation

Plasma levels were measured after both intravenous and oral dosing for typical pharmacokinetic and bioavailability studies to evaluate compound half-life and other typical characteristics that require an evaluation of a drug candidate

It also activates calpain proteases [71]

doi: 10.1038/cddis.2012.216