glutathione mitochondrial transport Human transferases: Kinetic parameters and accommodation of a mitochondria-targeting group in substrates Dual localization of glutathione S‐transferase

In renal clear cell carcinoma, disulfiram demonstrated potent antitumor activity by inhibiting NPL4, promoting oxidative stress, and inducing ferroptosis ( Furthermore, combination therapy with disulfiram and conventional chemotherapeutic agents (e.g., PARP inhibitors, sorafenib, doxorubicin) has demonstrated synergistic effects in vitro and in animal models, partially overcoming tumor resistance and improving therapeutic efficacy ( Through co-delivery via nanocarriers, precise release of disulfiram and metal ions can be achieved, enhancing drug stability and tumor targeting while reducing systemic toxicity ( 6 Conclusion and outlook As a major threat to mens health, urological cancers have shown an increasing incidence trend in recent years

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J Biol Chem 276:1427914288 Huang C, Anderson ME, Meister A (1993a) Amino acid sequence and function of the light subunit of rat kidney -glutamylcysteine synthetase