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One of its key roles is helping to recycle Vitamin C after it has done its job fighting off oxidative damage
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This activation can occur through direct interaction with the target mRNA to increase its stability or promote translation [284]
Nature 529 , 3742 (2016)
Firstly, Mn 2+ can directly bind to cGAS and induce the activation of cGAS protein to form a compact conformation that is more easily to be further activated
