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Signal Transduction and Targeted Therapy, 2 (1), 1-9

These symptoms may suggest inadequate B12 replacement, concurrent iron or folate deficiency, or alternative haematological conditions requiring investigation

When I first met with the MHRA in London years ago, they invited me down to an early morning meeting in London just to tell me there is nothing we can do to help It was expensive, frustrating and depressing and theres been many of those occasions over the years

1298A (leading to a Glu at amino acid 429) is the most common while 1298C (leading to an Ala substitution at amino acid 429) is less common

That's better than nothing, but it's not the same as Phase 2 safety data

While its primary energy substrate is glucose, in situations of glucose scarcity, KBs can cover up to 60% of its energy demand [75]