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showed that 13-oxo-ODE can activate PPAR, inducing transcriptional repression of pro-inflammatory factors and ameliorating colitis and mucosa inflammation in human epithelial colon cells, 170 whereas the two ALA-derived ketones, 9-oxo-OTrE and 13-oxo-OTrE inhibited inflammatory responses by significantly decreasing nitric oxide (NO) and TNF- release in a LPS-stimulated RAW 264.7 macrophage cell line