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What Happens in Intervertebral Disc Degeneration Intervertebral disc degeneration is characterized by progressive structural and biochemical changes, including: Loss of proteoglycan content Reduced water retention (disc desiccation) Decreased disc height Altered mechanical properties Increased susceptibility to herniation and annular fissures These changes disrupt spinal biomechanics and may contribute to pain, nerve compression, and reduced mobility

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then, I-b can bind to NF-B to inhibit its activation and, thus, reduce NSAID-induced intestinal injury (Watanabe et al., 2009)

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Against hypoglycemic seizures from insulin overdose, BPC-157 prevented brain lesions in cerebral cortex and hippocampus while simultaneously protecting the gut and liver, demonstrating unified cytoprotection