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Although targeting hexokinase with 2-DG alone is generally ineffective, it can sensitize AML cells to other drugs that affect mitochondria, including cytarabine, inhibitors of complex I of the ETC (such as rotenone), the mitochondrial uncoupler CCCP, and BH3-mimetic inhibitors of Bcl-2, like ABT-737 [13, 34, 35] (see Figs

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J Neuroinflammation 14(1):3 Kawano T, Anrather J, Zhou P, Park L, Wang G, Frys KA, Kunz A, Cho S et al (2006) Prostaglandin E 2 EP1 receptors: downstream effectors of COX-2 neurotoxicity

doi: 10.4238/2015.February.2.9