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The blood pressure-concentration plot presented clockwise hysteresis, similar to the subjective drug effect-concentration plots, indicating acute pharmacological tolerance ( Supplementary Figure S5 )

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mdpi.com A firstinhuman tolerability trial administering IV BPC-157 to healthy volunteers showed good safety profiles at doses up to 0.5 mg/kg, setting the stage for future clinical pharmacokinetic and safety assessments

It modulated an expression of both metalloproteinases and their inhibitors (TIMP-1 and TIMP-2), improving wound healing and facilitating skin remodeling processes [57]