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In 1951 Conley and Krevans from the Johns Hopkins Hospital challenged the practice, raising the possibility that the neurological manifestations in some new pernicious anemia patients may be linked to previously prescribed high oral doses of folic acid (2028 mg/d) (12)
"The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations"
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