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Ethics declarations Competing interests J.K.W., S.K., E.D., and B.J.D

Lab Invest 47:471476 Acknowledgements We wish to thank Professor Ann Smith for the initial suggestion to investigate the interaction of glutathione with heme

HIV/SIV infection and ART both compromise mtDNA integrity through direct and indirect mechanisms, leading to impaired oxidative phosphorylation, dysregulated reactive oxygen species, and altered mitochondrial dynamics
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