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There is spherocytosis

The correlation coefficient (r 2 ) observed was above 0.994

Supplementary material The Supplementary Material for this article can be found online at: References 1 AdelI

2 -ARs couple to inhibitory G proteins G i /G 0 resulting in an inhibition of AC and a decrease in cAMP formation (Albarrn-Jurez et al., 2009)

Even when standard serum B12 and folate levels appear normal, functional deficiencies in 5-methyltetrahydrofolate (5-MTHF) and methylcobalamin can limit mitochondrial ATP production and neurotransmitter synthesis, potentially driving persistent fatigue symptoms (13)

While this has not been confirmed in humans, it is considered a relative contraindication by most practitioners