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People with pernicious anemia or other medical conditions affecting B12 levels

Vitamin B12 is mostly stored in the liver and thus its deficiency can lead to an increased risk of liver disease and inflammation which is referred to as cirrhosis

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When activated, the complex leads to the cleavage of the proforms of the cytokines IL-1 and IL-18, which themselves become activated and secreted to further amplify inflammation and immune responses

[DOI] [PMC free article] [PubMed] [Google Scholar] 336.Moore, M

The peptide binds to beta-3 adrenergic receptors on adipocytes (fat cells), triggering a cascade of intracellular events that activate hormone-sensitive lipase (HSL)