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Systemic nitric oxide Synthase inhibition does not affect brain oxygenation during cortical spreading depression in rats: a noninvasive near-infrared spectroscopy and laser-Doppler Flowmetry study

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Future studies should focus on developing combinatorial strategies, such as identifying optimal pairings of exercise modalities (e.g., high-intensity interval training versus moderate-intensity endurance training) with specific classes of Chinese herbal medicine, elucidating the cross-regulation mechanisms within the Nrf2/NF-B/AMPK signaling network, and establishing individualized intervention protocols that integrate exercise with botanical treatment for ALD patients

A short break (2-4 weeks) is often recommended before starting again

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