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the present invention encompasses methods for treating, preventing, or managing a disease or disorder associated with overexpression of EphA2 or EphA4 and/or a cell hyperproliferative disorder, particularly cancer, in a subject comprising administering an effective amount of a composition that can target cells expressing EphA2 or EphA4, and inhibiting the EphA2 or EphA4 expression or function, and/or having therapeutic or prophylactic effects on the hyperproliferative cell disease

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The regulation of GLS1 is not limited to TGF-

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From an oxygen transport point of view, the Embden-Meyerhof pathway serves principally the generation of 2,3-BPG, because in terms of quantity, it is the principal glycolytic intermediate: the concentration of 2,3-BPG is about equal to the sum of all other glycolytic intermediates