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Studies revealed that by increasing the concentrations of the cytosolic cysteine, and thus glutathione of monocytes and macrophages using a synthetic form of cysteine called NAC, blocks H 2 O 2 mediated activation of NF-kB, and thus pro-inflammatory cytokines (tumor necrosis factors [TNF]-, interleukin [IL]-1 and IL-6) by this route

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At present, a Nrf2 agonist has received clinical approval

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Tamouza H, Vende F, Tiwari M, Arcos-Fajardo M, Vrtovsnik F, Benhamou M, et al

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