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Anti-androgens such as finasteride, flutamide, spironolactone, or bicalutamide, along with lifestyle modifications, are more effective in improving hirsutism, SHBG, fasting insulin, and the fasting insulin:glucose ratio

Moreover, DON treatment sensitizes pancreatic tumors to immune checkpoint blockade therapy, resulting in tumor growth inhibition and prolonged survival (Sharma et al., 2020)

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