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Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis

Similarly, adipose tissue, in particular visceral fat, secretes pro-inflammatory adipocyte-derived cytokines and exhibits higher levels of C-reactive protein (CRP), TNF- receptor 2, and IL-6 than non-obese individuals ( The association between SLE risk and diet is less clear in humans ( Several studies have reported an association between lack of sleep and SLE risk in humans (93102)

Vitamin C: In one study, taking 500 or 1,000 mg per day of vitamin C for 13 weeks led to an increase of 18% of the glutathione levels in lymphocytes

eLife 5 , e16351 (2016)

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On the other hand, it acts as an interacting hub for various signaling pathways, including the mTORC1 pathway [281], which inhibits autophagy