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Chitosan and its derivatives have also demonstrated significant advantages in nasal drug delivery by enhancing residence time through strong mucoadhesion while simultaneously promoting epithelial interaction and transient opening of tight junctions, thereby facilitating drug absorption without relying solely on high bulk viscosity (Casettari and Illum, 2014)

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Acknowledgements This work was supported in part by the Ministry of Education, Culture, Sports, Science and Technology of Japan: Grant-in-aid for Scientific Research on Innovative Areas (26116713, J.-M

The dashed line indicates the threshold for neutralizing activity

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This medicine is given via a needle inserted into the muscle beneath the skin