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Trends Neurosci (1985) 8:7983

The widgets are electrons

Abstract A challenge in neuroscience is to understand the mechanisms underlying synapse formation

Initial glow in 34 weeks, deeper improvements in 68 weeks

Compound time-of-addition (TOA) analysis suggests differential modes of antiviral activity In order to get first insights into the potential mode-of-action exerted by the two compounds against the viruses investigated, we performed time-of-addition assays

The simultaneous interaction with the endogenous Ub-E2-E3 complex and the protein of interest results in the generation of an Ub-E2-E3-neosubstrate complex, ultimately leading to ubiquitinylation and degradation of target protein