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Research in mice given 5-amino-1MQ showed a 7% reduction in body mass without any changes in food intake, compared to controls
As well as causing B12 deficiency, an increase in methylmalonic acid occurs, which is thought to result in loss of myelin in the peripheral nerves and, consequently, neuropathy, which may be symptomatic as early as 2 years into metformin treatment

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My daughter was diagnosed with B12 deficiency last year and her B12 test results said her level was so low it was unable to be read
