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Metabolism abnormalities induced by exposure to excessive UA are important factors mediating the pathological development of HUA-associated multiple organ complications ( via UA excretion agent benzbromarone therapy ( via regulating transforming growth factor 1, nicotinamide adenine dinucleotide phosphate oxidase and AMP-activated protein kinase mediated reactive oxygen species and inflammation (Madlala et al., 2016
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Duration: Many weeks to months, commonly 12 weeks or longer in human studies that demonstrated measurable increases in muscle carnitine
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doi: 10.1021/acschemneuro.9b00336
