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Beyond epigenetic regulation, metabolic reprogramming has also emerged as a critical determinant of macrophage functional polarization

Moreover, HO-1 may stand for some clinical characteristics of PD, including neuroinflammation, oxidative stress, dysregulated iron metabolism, and mitochondrial damage

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Metwalli AR, Rosner IL, Cullen J, Chen Y, Brand T, Brassell SA, Lesperance J, Porter C, Sterbis J, McLeod DG (2014) Elevated alkaline phosphatase velocity strongly predicts overall survival and the risk of bone metastases in castrate-resistant prostate cancer

10.1007/s10803-006-0079-0 J

When the patients were divided into two groups such as the higher and lower groups according to the median value of GPX-3 concentration of 82.8 ng/mL, in Kaplan Meier survival analysis, however, no significant difference in cumulative patients survival rates between patients in the higher and lower groups was observed (Supplementary Figure S2)