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Poor nutrition can cause hair thinning and loss

B12 is an essential precursor in the methylation cycle and the folate cycle

Significant healing needs that affect quality of life may justify accepting theoretical risks that would be unacceptable for minor issues

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When someone arrives with a significant deficiency, their stores are low, their red blood cells may be enlarged (macrocytosis), and, in longstanding cases, nerve function can be affected

A Phase 2b clinical trial (Heffernan 2007, 300 obese patients) tested 1 mg/day subcutaneously over 12 weeks with a weight loss result of ~2.8 kg vs placebo