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Acknowledgements This work was supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project (2023ZD0507200), National Natural Science Foundation of China (32070961), Natural Science Foundation of Sichuan Province (2024NSFSC1643), Sichuan University Postdoctoral Interdisciplinary Innovation Fund (JCXK2206), and Postdoctoral Research Program of West China Hospital, Sichuan University (2023HXBH126)