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Terpos et al., 2015)

To evaluate the experimental repeatability, the 180 d sample was split, filtered through two membranes and analysed as technical duplicates (180 d_1 and 180 d_2)

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For example, patients with a predicted probability 0.25 (low risk) may be considered for conservative management, which is expected to significantly reduce the negative appendectomy rate and associated surgical risks ( Compared with models such as the AAS grade or RIPASA score, which rely on subjective clinical signs, the strength of this study lies in its complete dependence on objective laboratory and imaging parameters, thereby avoiding inter-observer variability in physical examination and patient-reported bias ( It must be acknowledged that, as a single-center retrospective analysis, this study inevitably carries limitations such as selection bias

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