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Moreover, studies using isolated mitochondria from rat skeletal muscle found that ROS production occurred at 11 sites associated with substrate oxidation and oxidative phosphorylation 9

Cr: 0.972

This glutathione depletion is sufficient for erastin-dependent cell death, as glutathione depletion by another reagent, buthionine sulfoxamine (BSO), also initiated ferroptosis [24]

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In KU-57788-treated ATC cells, 8505C and Hth-7, numerous vacuoles were observed under bright-field phase-contrast microscopy (Fig