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Como qualquer substncia biologicamente ativa, eles podem provocar efeitos colaterais

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hence, the S/R plasma concentrations decrease with time after each dose (2)

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La supplmentation devient particulirement pertinente en cas de vgtalisme ou faible consommation de viande , de troubles digestifs chroniques (Crohn, maladie cliaque, gastrite), de maladie de Biermer , lors de la prise de certains mdicaments qui rduisent labsorption, ou encore avec lge , lorsque la scrtion dacide gastrique diminue