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Data sharing not applicable to this article as no datasets were generated or analyzed during the current study

Redirecting TGF- Signaling through the -Catenin/Foxo complex prevents kidney fibrosis

ATP-binding cassette transporter A4 (ABCA4) facilitates the transport of atRAL from the outer segment discs of photoreceptors to the cytoplasm, while all-trans retinol dehydrogenase 8 (RDH8) catalyses the conversion of atRAL back to all-trans retinol (260)

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Retatrutide represents a promising pipeline compound that could expand the therapeutic toolkit, especially for patients with concurrent MASLD/MASH where glucagon-mediated hepatic fat oxidation may provide additional benefit