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While the accumulation of peroxidized lipids is a hallmark of ferroptosis, their primary role is to serve as the lethal substrate that overwhelms and functionally inactivates the GPX4 system when antioxidant defenses are insufficient, rather than directly binding to and inhibiting the enzyme perse (115, 116)

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Cross-linked enzyme aggregates (CLEAs) of selected lipases: a procedure for the proper calculation of their recovered activity

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Giordano '12 * James W