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Description

Am J Addict 13: 181190

Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2)

Studies show it enhances IGF-1 expression in liver and skeletal muscle, particularly with high-protein diets, and activates pathways like PI3K/AKT/mTOR for muscle growth

Importantly, the process does not involve the CYP450 enzyme system, showing no inhibitory or inductive effect on clinically significant isoforms such as CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4

Considering all these factors, vitamin D deficiency during pregnancy and early childhood can negatively affect brain development of children and cause many neuropsychological disorder, especially ASD [96]