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Additional hurdles include the risk of off-target effects in mtDNA or the nuclear genome, potential immune responses to the editing machinery, and substantial technical and regulatory barriers that complicate translation of in vivo gene editing into clinical practice
Patients received standard GH therapy with a subcutaneous recombinant growth hormone injection (Genotropin, Pfizer, USA, or Norditropin, Novo Nordisk, Denmark)
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ALPHA-ARBUTIN Alpha-arbutin, a natural skin-brightening ingredient
Jeong JJ, Ha YM, et al
Semin Thorac Cardiovasc Surg S1043-0679(17):30295-2, 2017
