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Treatment with vitamin B-12 increased serum total vitamin B-12, serum holoTC, and c-B12, and reduced plasma tHcy and serum MMA ( P 50% lower holoTC concentration compared with vitamin B-12deficient participants with nonelevated folate ( Figure 8 A)

In the long-term toxicity experiment, continuous injection of AOD 9604 (10 mg/kg) for 8 weeks did not cause abnormal liver and kidney functions or fluctuations in blood glucose, providing a safety basis for its further research and application

Mller P, Fischer H, Sorger D

Tell your doctor if you are pregnant or breast-feeding or if you have any medical condition such as liver or kidney disease

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