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A May 2025 study in Molecular Therapy from the INc-UAB showed that gene therapy increasing secreted klotho (s-KL) in mice extended lifespan by 15-20% while improving muscle, bone, and cognitive health at 24 months of age (equivalent to ~70 human years)
doi: 10.1016/j.taap.2004.10.004

Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19

CM was replaced every 48 h

Diabetes Care 47 , 13251332 (2024)

Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex Glycyl-L-histidyl-L-lysine-Cu2+
