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Fiorentino TV, Casiraghi F, Davalli AM, et al (2019) Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas

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PKM2 not only accelerates cytoplasmic glycolysis (increasing lactate production by 22%) but also translocates to the nucleus to synergize with HIF-1 in upregulating glycolytic genes

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This binding site leaves the catalytic sites Cys302 and Glu268 unimpeded ( Fig