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The transdifferentiation of hepatic stellate cells (HSCs) into matrix-producing myofibroblasts is considered a key step in the development of liver fibrosis [81]

doi: 10.1016/j.tins.2019.01.003, 85

doi: 10.1016/j.chroma.2023.464358 42

Various reactive nitrogen species (RNS) and ROS act as fuel for inflammatory processes by prompting the production of proinflammatory cytokines and adhesion related components via NF-B pathway activation

Mol Hum Reprod 26:353365

Another involvement of NO is in modification of Cys residues following several reaction steps to form R-S-NO (FIGURE 1)