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However, for the sake of completeness, we also note that there is also a single reference that HoloTC is not superior to total B 12 [84]

Chen, C., Yan, S., Geng, Z

Excess Fe 2+ can donate electrons to H 2 O 2 and O 2 , resulting in substantial production of O 2 and OH free radicals which may cause lipid peroxidation of neuronal membranes as well as accelerated generation of guanidine compounds in the brain, ultimately leading to epileptic conditions (51)

As a novel PTM, lactylation has been extensively studied, revealing its pivotal involvement in the development and progression of various diseases, including melanoma, myocardial infarction, hepatocellular carcinoma, Alzheimers disease, and nonalcoholic fatty liver disease [18,19,20,21,22,23,24]