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PD-linked mutations may interfere with any of these pathways, leading, e.g., to decreased lysosomal degradation of -synuclein aggregates or increased aggregation of -synuclein due to oxidative damage downstream of ROS release from defective mitochondria
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12 Subsequently, three additional CFTR modulators were approved by the FDA, prompting a guideline update focusing on CFTR modulators in 2018
doi:10.1002/lary.24099 Mikulec AA, Kowalczyk KA, Pfitzinger ME, Harris DA, Jackson LE
