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In Drosophila , both overexpression and knockdown of HDAC4 impair memory, suggesting that HDAC4 is both a repressor when in excess and essential for normal memory function [47]

(-, -6)

All animals were treated humanely, and all studies were carried out in accordance with good laboratory practice (GLP) (China Food and Drug Administration, CFDA) guidelines for nonclinical laboratory studies of drugs issued by the National Scientic and Technological Committee of the Peoples Republic of China

patents, and has been affiliated with various academic and scientific institutions

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This review asks a deliberately narrow, evidence-first question: does the existing preclinical literature actually support a safety conclusion for BPC-157 and TB-500 in rodent toxicology models, or does it merely show an absence of obvious harm in studies designed to measure something else