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In animal models and human studies, 6-hydroxydopamine was found to have antiparkinson effects resulting from components other than LDs or enhancing LDs [36]

In pancreatic cells, excessive production of ROS promotes cell dysfunction and apoptosis, ultimately leading to insufficient insulin secretion [124]

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Notably, since menaquinole and demethylmenaquinole reoxidise quickly 20 and might not be detectable in our assay, we cannot exclude that LhgO may accept also these quinones as electron acceptors